Worldwide at least 200 per 100,000 people are killed or admitted to hospital each year after traumatic brain injury. This results in more than 10 million deaths or hospitalisations each year. Traumatic brain injuries are the leading cause of death and disability in people below the age of 45.
The effectiveness and safety of tranexamic acid in acute severe bleeding is being evaluated in a suite of large scale trials. Some of these trials are complete and the results are available whereas others are on-going.
Each year, worldwide, nearly six million people die from trauma, many after reaching hospital. Among trauma patients who survive to reach hospital, extra-cranial bleeding is a common cause of death, accounting for around 40% of in-hospital deaths.
Spontaneous intracerebral haemorrhage (haemorrhagic stroke) is a leading cause of death and disability worldwide. Although there are effective treatments for ischaemic stroke (e.g. thrombolysis, aspirin) there are no proven treatments for intracerebral haemorrhage.